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1

The first human clinical study for NMN has started in Japan

Journal:

npj Aging and Mechanisms of Disease

Year:

2016

Language:

english

File:

PDF, 223 KB

english, 2016

2

TFOS DEWS II Definition and Classification Report

Craig, Jennifer P., Nichols, Kelly K., Akpek, Esen K., Caffery, Barbara, Dua, Harminder S., Joo, Choun-Ki, Liu, Zuguo, Nelson, J. Daniel, Nichols, Jason J., Tsubota, Kazuo, Stapleton, Fiona

Journal:

The Ocular Surface

Year:

2017

Language:

english

File:

PDF, 1.40 MB

english, 2017

3

Exercise program improved subjective dry eye symptoms for office workers

Sano, Kokoro, Kawashima, Motoko, Takechi, Sayuri, Mimura, Masaru, Tsubota, Kazuo

Journal:

Clinical Ophthalmology

Year:

2018

Language:

english

File:

PDF, 521 KB

english, 2018

4

Vision Loss by Central Retinal Vein Occlusion After Kaatsu Training

Ozawa, Yoko, Koto, Takashi, Shinoda, Hajime, Tsubota, Kazuo

Journal:

Medicine (Medicine Publishing Company Ltd)

Year:

2015

Language:

english

File:

PDF, 175 KB

english, 2015

5

Advances in the diagnosis and treatment of dry eye

Kojima, Takashi, Dogru, Murat, Kawashima, Motoko, Nakamura, Shigeru, Tsubota, Kazuo

Journal:

Progress in Retinal and Eye Research

Year:

2020

File:

PDF, 5.48 MB

2020

6

Functional Corneal Endothelium Derived from Corneal Stroma Stem Cells of Neural Crest Origin by Retinoic Acid and Wnt/β-Catenin Signaling

Hatou, Shin, Yoshida, Satoru, Higa, Kazunari, Miyashita, Hideyuki, Inagaki, Emi, Okano, Hideyuki, Tsubota, Kazuo, Shimmura, Shigeto

Journal:

Stem Cells and Development

Year:

2013

Language:

english

File:

PDF, 1.78 MB

english, 2013

7

The effect of autologous serum eyedrops in the treatment of severe dry eye disease: A prospective randomized case-control study

Takashi Kojima, Reiko Ishida, Murat Dogru, Eiki Goto, Yukihiro Matsumoto, Minako Kaido, Kazuo Tsubota

Journal:

American Journal of Ophthalmology

Year:

2005

Language:

english

File:

PDF, 119 KB

english, 2005

8

Prevalence and Risk Factors of Dry Eye Disease in Japan: Koumi Study

Miki Uchino, Yuji Nishiwaki, Takehiro Michikawa, Kazuhiro Shirakawa, Erika Kuwahara, Mutsuko Yamada, Murat Dogru, Debra A. Schaumberg, Tetsuya Kawakita, Toru Takebayashi, Kazuo Tsubota

Journal:

Year:

2011

Language:

english

File:

PDF, 210 KB

english, 2011

9

Porous Silk Fibroin Film as a Transparent Carrier for Cultivated Corneal Epithelial Sheets

Higa, Kazunari, Takeshima, Naomi, Moro, Fumika, Kawakita, Tetsuya, Kawashima, Motoko, Demura, Makoto, Shimazaki, Jun, Asakura, Tetsuo, Tsubota, Kazuo, Shimmura, Shigeto

Journal:

Journal of Biomaterials Science Polymer Edition

Year:

2011

Language:

english

File:

PDF, 10.05 MB

english, 2011

10

Bilberry extract supplementation for preventing eye fatigue in video display terminal workers

Ozawa, Y., Kawashima, M., Inoue, S., Inagaki, E., Suzuki, A., Ooe, E., Kobayashi, S., Tsubota, Kazuo

Journal:

The Journal of Nutrition, Health & Aging

Year:

2015

Language:

english

File:

PDF, 257 KB

english, 2015

11

Japan as the front-runner of super-aged societies: Perspectives from medicine and medical care in Japan

Arai, Hidenori, Ouchi, Yasuyoshi, Toba, Kenji, Endo, Tamao, Shimokado, Kentaro, Tsubota, Kazuo, Matsuo, Seiichi, Mori, Hidezo, Yumura, Wako, Yokode, Masayuki, Rakugi, Hiromi, Ohshima, Shinichi

Journal:

Geriatrics & Gerontology International

Year:

2015

Language:

english

File:

PDF, 167 KB

english, 2015

12

Classification of Fluorescein Breakup Patterns: A Novel Method of Differential Diagnosis for Dry Eye

Yokoi, Norihiko, Georgiev, Georgi As, Kato, Hiroaki, Komuro, Aoi, Sonomura, Yukiko, Sotozono, Chie, Tsubota, Kazuo, Kinoshita, Shigeru

Journal:

American Journal of Ophthalmology

Year:

2017

Language:

english

File:

PDF, 964 KB

english, 2017

13

The effects of 3% diquafosol sodium eye drop application on meibomian gland and ocular surface alterations in the Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice

Ikeda, Keisuke, Simsek, Cem, Kojima, Takashi, Higa, Kazunari, Kawashima, Motoko, Dogru, Murat, Shimizu, Takahiko, Tsubota, Kazuo, Shimazaki, Jun

Journal:

Graefe's Archive for Clinical and Experimental Ophthalmology

Year:

2018

Language:

english

File:

PDF, 11.26 MB

english, 2018

14

Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan

Uchino, Miki, Yokoi, Norihiko, Kawashima, Motoko, Ryutaro, Yamanishi, Uchino, Yuichi, Tsubota, Kazuo

Journal:

Journal of Clinical Medicine

Year:

2019

Language:

english

File:

PDF, 202 KB

english, 2019

15

Efficacy of Plate Expression of Meibum on Tear Function and Ocular Surface Findings in Meibomian Gland Disease

Aketa, Naohiko, Shinzawa, Megumi, Kawashima, Motoko, Dogru, Murat, Okamoto, Shosei, Tsubota, Kazuo, Shimazaki, Jun

Journal:

Eye & Contact Lens Science & Clinical Practice

Year:

2019

Language:

english

File:

PDF, 173 KB

english, 2019

16

A New Perspective on Dry Eye Classification

Tsubota, Kazuo, Yokoi, Norihiko, Watanabe, Hitoshi, Dogru, Murat, Kojima, Takashi, Yamada, Masakazu, Kinoshita, Shigeru, Kim, Hyo-Myung, Tchah, Hung-Won, Hyon, Joon Young, Yoon, Kyung Chul, Seo, Kyoun

Journal:

Eye & Contact Lens Science & Clinical Practice

Year:

2020

File:

PDF, 1.16 MB

2020

17

Collagen immobilized PVA hydrogel-hydroxyapatite composites prepared by kneading methods as a material for peripheral cuff of artificial cornea

Hisatoshi Kobayashi, Masabumi Kato, Tetsushi Taguchi, Toshiyuki Ikoma, Hideyuki Miyashita, Shigeto Shimmura, Kazuo Tsubota, Junzo Tanaka

Journal:

Materials Science and Engineering: C

Year:

2004

Language:

english

File:

PDF, 1.69 MB

english, 2004

18

A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details

Hisanori Umehara, Kazuichi Okazaki, Yasufumi Masaki, Mitsuhiro Kawano, Motohisa Yamamoto, Takako Saeki, Shoko Matsui, Takayuki Sumida, Tsuneyo Mimori, Yoshiya Tanaka, Kazuo Tsubota, Tadashi Yoshino, S

Journal:

Modern Rheumatology

Year:

2012

Language:

english

File:

PDF, 730 KB

english, 2012

19

The effects of 2 week senofilcon—A silicone hydrogel contact lens daily wear on tear functions and ocular surface health status

Murat Dogru, Samantha K. Ward, Tais Wakamatsu, Osama Ibrahim, Cristina Schnider, Takashi Kojima, Yukihiro Matsumoto, Junko Ogawa, Jun Shimazaki, Kazuo Tsubota

Journal:

Contact Lens and Anterior Eye

Year:

2011

Language:

english

File:

PDF, 147 KB

english, 2011

20

Ocular Surface Management in Corneal Transplantation, a Review

Journal:

Japanese Journal of Ophthalmology

Year:

1999

Language:

english

File:

PDF, 4.19 MB

english, 1999

21

Repair of blowout orbital floor fracture by periosteal suturing

Mika Noda, Kousuke Noda, Shinji Ideta, Yasuhisa Nakamura, Susumu Ishida, Makoto Inoue, Kazuo Tsubota

Journal:

Clinical & Experimental Ophthalmology

Year:

2011

Language:

english

File:

PDF, 616 KB

english, 2011

22

Trabeculectomy With or Without Intraoperative Sub-Tenon Injection of Triamcinolone Acetonide in Treating Secondary Glaucoma

Kenya Yuki, Daisuke Shiba, Itaru Kimura, Yuichiro Ohtake, Kazuo Tsubota

Journal:

American Journal of Ophthalmology

Year:

2009

Language:

english

File:

PDF, 407 KB

english, 2009

23

Risk factors and retreatment results of intraoperative flap complications in LASIK

Mitsutoshi Ito, Yoshiko Hori-Komai, Ikuko Toda, Kazuo Tsubota

Journal:

Journal of Cataract & Refractive Surgery

Year:

2004

Language:

english

File:

PDF, 159 KB

english, 2004

24

Meibomian gland dysfunction in patients with Sjögren syndrome

Jun Shimazaki, Eiki Goto, Masafumi Ono, Shigeto Shimmura, Kazuo Tsubota

Journal:

Year:

1998

Language:

english

File:

PDF, 204 KB

english, 1998

25

Effects of Diquafosol Tetrasodium Administration on Visual Function in Short Break-Up Time Dry Eye

Kaido, Minako, Uchino, Miki, Kojima, Takashi, Dogru, Murat, Tsubota, Kazuo

Journal:

Journal of Ocular Pharmacology and Therapeutics

Year:

2013

Language:

english

File:

PDF, 311 KB

english, 2013

26

Clinical and Molecular Analysis of Stargardt Disease With Preserved Foveal Structure and Function

Fujinami, Kaoru, Sergouniotis, Panagiotis I., Davidson, Alice E., Wright, Genevieve, Chana, Ravinder K., Tsunoda, Kazushige, Tsubota, Kazuo, Egan, Catherine A., Robson, Anthony G., Moore, Anthony T.,

Journal:

American Journal of Ophthalmology

Year:

2013

Language:

english

File:

PDF, 3.98 MB

english, 2013

27

Changing trends in the treatment of dry-eye disease

Dogru, Murat, Nakamura, Masatsugu, Shimazaki, Jun, Tsubota, Kazuo

Journal:

Expert Opinion on Investigational Drugs

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

28

Prevalence of Dry Eye Disease and its Risk Factors in Visual Display Terminal Users: The Osaka Study

Uchino, Miki, Yokoi, Norihiko, Uchino, Yuichi, Dogru, Murat, Kawashima, Motoko, Komuro, Aoi, Sonomura, Yukiko, Kato, Hiroaki, Kinoshita, Shigeru, Schaumberg, Debra A., Tsubota, Kazuo

Journal:

American Journal of Ophthalmology

Year:

2013

Language:

english

File:

PDF, 493 KB

english, 2013

29

The effect of tinted soft contact lens wear on functional visual acuity and higher-order aberrations

Watanabe, Kazuhiro, Kaido, Minako, Ishida, Reiko, Dogru, Murat, Negishi, Kazuno, Tsubota, Kazuo

Journal:

Contact Lens and Anterior Eye

Year:

2014

Language:

english

File:

PDF, 715 KB

english, 2014

30

Efficacy and Safety of Diquafosol Ophthalmic Solution in Patients with Dry Eye Syndrome: A Japanese Phase 2 Clinical Trial

Matsumoto, Yukihiro, Ohashi, Yuichi, Watanabe, Hitoshi, Tsubota, Kazuo

Journal:

Year:

2012

Language:

english

File:

PDF, 508 KB

english, 2012

31

Biological effects of blocking blue and other visible light on the mouse retina

Narimatsu, Toshio, Ozawa, Yoko, Miyake, Seiji, Kubota, Shunsuke, Yuki, Kenya, Nagai, Norihiro, Tsubota, Kazuo

Journal:

Clinical & Experimental Ophthalmology

Year:

2014

Language:

english

File:

PDF, 679 KB

english, 2014

32

Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo

Narimatsu, Toshio, Negishi, Kazuno, Miyake, Seiji, Hirasawa, Manabu, Osada, Hideto, Kurihara, Toshihide, Tsubota, Kazuo, Ozawa, Yoko

Journal:

Experimental Eye Research

Year:

2015

Language:

english

File:

PDF, 493 KB

english, 2015

33

Evaluation of Surgical Outcomes for Ptosis Surgery by Face Recognition Software

Ideta, Shinji, Ota, Yu, Yuki, Kenya, Noda, Mika, Inoue, Makoto, Tsubota, Kazuo

Journal:

Asia-Pacific Journal of Ophthalmology

Year:

2015

Language:

english

File:

PDF, 1.69 MB

english, 2015

34

Complications with One-piece Lamellar Keratolimbal Grafts for Simultaneous Limbal and Corneal Pathologies

Shimmura, Shigeto, Ando, Masako, Shimazaki, Jun, Tsubota, Kazuo

Journal:

Year:

2000

Language:

english

File:

PDF, 1.23 MB

english, 2000

35

Effect of Blue Light–Reducing Eye Glasses on Critical Flicker Frequency

Ide, Takeshi, Toda, Ikuko, Miki, Emiko, Tsubota, Kazuo

Journal:

Asia-Pacific Journal of Ophthalmology

Year:

2015

Language:

english

File:

PDF, 1.41 MB

english, 2015

36

OCT Assessment of Tear Meniscus After Punctal Occlusion in Dry Eye Disease

Ibrahim, Osama M. A., Dogru, Murat, Kojima, Takashi, Matsumoto, Yukihiro, Wakamatsu, Tais Hitomi, Tsubota, Kazuo, Fujishima, Hiroshi

Journal:

Optometry and Vision Science

Year:

2012

Language:

english

File:

PDF, 928 KB

english, 2012

37

A New Mouse Model of Dry Eye Disease

Uchino, Yuichi, Kawakita, Tetsuya, Ishii, Takamasa, Ishii, Naoaki, Tsubota, Kazuo

Journal:

Year:

2012

Language:

english

File:

PDF, 722 KB

english, 2012

38

Effect of Oral Pilocarpine in Treating Severe Dry Eye in Patients With Sjögren Syndrome

Kawakita, Tetsuya, Shimmura, Shigeto, Tsubota, Kazuo

Journal:

Asia-Pacific Journal of Ophthalmology

Year:

2015

Language:

english

File:

PDF, 351 KB

english, 2015

39

Dry Eye in Diabetes Mellitus

Ogawa, Yoko, Kamoshita, Izumi, Yoshino, Kenichi, Ono, Masafumi, Tsubota, Kazuo

Journal:

International Ophthalmology Clinics

Year:

1994

File:

PDF, 68 KB

1994

40

Tear Film and Ocular Surface Abnormalities After Eyelid Tattooing

Kojima, Takashi, Dogru, Murat, Matsumoto, Yukihiro, Goto, Eiki, Tsubota, Kazuo

Journal:

Ophthalmic Plastic & Reconstructive Surgery

Year:

2005

Language:

english

File:

PDF, 815 KB

english, 2005

41

New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society

Tsubota, Kazuo, Yokoi, Norihiko, Shimazaki, Jun, Watanabe, Hitoshi, Dogru, Murat, Yamada, Masakazu, Kinoshita, Shigeru, Kim, Hyo-Myung, Tchah, Hung-Won, Hyon, Joon Young, Yoon, Kyung-Chul, Seo, Kyoung

Journal:

The Ocular Surface

Year:

2016

Language:

english

File:

PDF, 1.83 MB

english, 2016

42

Sleep and mood disorders in women with dry eye disease

Ayaki, Masahiko, Kawashima, Motoko, Negishi, Kazuno, Kishimoto, Taishiro, Mimura, Masaru, Tsubota, Kazuo

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 622 KB

english, 2016

43

Long-term homeostasis and wound healing in an in vitro epithelial stem cell niche model

Miyashita, Hideyuki, Niwano, Hiroko, Yoshida, Satoru, Hatou, Shin, Inagaki, Emi, Tsubota, Kazuo, Shimmura, Shigeto

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.54 MB

english, 2017

44

Effects of functional milk containing galactooligosaccharide, maltitol, and glucomannan on the production of hydrogen gas in the human intestine

Matsumoto, Mitsuharu, Fujita, Ayako, Yamashita, Ayano, Kameoka, Shoichiro, Shimomura, Yumi, Kitada, Yusuke, Tamada, Hazuki, Nakamura, Shigeru, Tsubota, Kazuo

Journal:

Journal of Functional Foods

Year:

2017

Language:

english

File:

PDF, 2.72 MB

english, 2017

45

Aging science comes of age

Journal:

npj Aging and Mechanisms of Disease

Year:

2015

Language:

english

File:

PDF, 202 KB

english, 2015

46

Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population

Sasaki, Mariko, Harada, Sei, Kawasaki, Yumiko, Watanabe, Miki, Ito, Hidemi, Tanaka, Hideo, Takeuchi, Ayano, Tsubota, Kazuo, Takebayashi, Toru, Nishiwaki, Yuji, Kawasaki, Ryo

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 1.03 MB

english, 2018

47

Ocular Surface and Tear Film Characteristics in a Sclerodermatous Chronic Graft-Versus-Host Disease Mouse Model

He, Jingliang, Yamane, Mio, Shibata, Shinsuke, Fukui, Masaki, Shimizu, Eisuke, Yano, Tetsuya, Mukai, Shin, Kawakami, Yutaka, Li, Shaowei, Tsubota, Kazuo, Ogawa, Yoko

Journal:

Year:

2018

Language:

english

File:

PDF, 1.38 MB

english, 2018

48

Randomized Controlled Study to Investigate the Effect of Topical Diquafosol Tetrasodium on Corneal Sensitivity in Short Tear Break-Up Time Dry Eye

Kaido, Minako, Kawashima, Motoko, Shigeno, Yuta, Yamada, Yoshiaki, Tsubota, Kazuo

Journal:

Advances in Therapy

Year:

2018

Language:

english

File:

PDF, 654 KB

english, 2018

49

Impact of lifestyle intervention on dry eye disease in office workers: a randomized controlled trial

Kawashima, Motoko, Sano, Kokoro, Takechi, Sayuri, Tsubota, Kazuo

Journal:

Journal of Occupational Health

Year:

2018

Language:

english

File:

PDF, 294 KB

english, 2018

50

Absolute and estimated values of macular pigment optical density in young and aged Asian participants with or without age-related macular degeneration

Ozawa, Yoko, Shigeno, Yuta, Nagai, Norihiro, Suzuki, Misa, Kurihara, Toshihide, Minami, Sakiko, Hirano, Eri, Shinoda, Hajime, Kobayashi, Saori, Tsubota, Kazuo

Journal:

BMC Ophthalmology

Year:

2017

Language:

english

File:

PDF, 405 KB

english, 2017